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Treatment refusal and abandonment are major causes of treatment failure for children with cancer in low- and middle-income countries (LMICs), like Guatemala. This study identified risk factors for and described the intervention that decreased abandonment. This was a retrospective study of Guatemalan children (0-18 years) with cancer treated at the Unidad Nacional de Oncología Pediátrica (UNOP), 2001-2008, using the Pediatric Oncology Network Database. Treatment refusal was a failure to begin treatment and treatment abandonment was a lapse of 4 weeks or longer in treatment. The impact of medicina integral, a multidisciplinary psychosocial intervention team at UNOP was evaluated. Cox proportional hazards analysis identified the effect of demographic and clinical factors on abandonment. Kaplan-Meier analysis estimated the survival. Of 1,789 patients, 21% refused or abandoned treatment. Abandonment decreased from 27% in 2001 to 7% in 2008 following the implementation of medicina integral. Factors associated with increased risk of refusal and abandonment: greater distance to the centre (P
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Water scientists and managers regularly observe how wetlands, whether natural or created, can mitigate the influence of artificial impervious surfaces on water quality. However, we rarely study or mention wetlands accidentally (sensu Palta et al. 2017) formed atop impervious surfaces. This silence occurs even though many urbanites have likely noticed sedges rimming a clogged drainage grate or in the low bits of a poorly graded or aging parking lot, or similar. A more extreme example occurs in the Little River Waterfowl Impoundment vicinity of the Butner-Falls of Neuse Game Land in Durham, North Carolina. There, a macadam road that connected local residents and a store, and served as the primary route through the area, by 1910-1920, was apparently abandoned by 1951. Later, damming nearby downstream Falls Lake Reservoir in 1981, and smaller-scale construction locally, apparently increased water table depth and flow exposure. Yet, the road remains largely intact structurally, though mostly buried and sometimes underwater. In a particularly wet segment of the road, surrounded by and partially holding back standing water even in drought, a substantial, mostly native wetland plant community has formed. This community includes trees such as overcup oak (Quercus lyrata) as large as 15 cm in diameter, shrubs such as (Cephalanthus occidentalus), sedges such as woolgrass (Scirpus cyperinus), rushes (multiple Juncus species), grasses such as wood oats (Chasmanthium latifolium), crayfish and fish, and multiple orders of herptiles. The plants grow rooted in fluffy sediment three to rarely more than 20cm deep, over solid pavement. Alongside the old road, the ditches have widened and become shallower and less surficially connected through tree roots and debris dams; they resemble pools. Sediment in these abandoned ditches has accumulated to depths of tens of centimeters, generally reforming a clay-dominated, gleyed soil, in some places buried under more tens of centimeters of very 2ff7e9595c
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